 Polymer Drug ConjugatesOver the last 10 years, JMPS has developed substantial expertise and proficiency in polymer drug conjugate chemistry. Our team of accomplished scientists effectively plan and execute the development and scale-up processes for linking small molecule payloads to polymers in support of PDCs, ADCs, and other drug delivery applications. You can trust Johnson Matthey as your CMO/CRO partner for development and production services throughout the lifecycle of your PDC.
Manufacturing and Technical StrengthsChemical Process Development- Ready to meet challenges associated with payload distribution, agglomeration, molecular weight determination and purification.
Analytical Method Development and Validation- GPC/SEC for molecular weight determination.
- MALS detection
Large Scale cGMP Manufacturing- High potency capabilities including SafeBridge® Category 4
- Controlled substances Schedule I-V
- Large scale chromatography
- Tangential flow filtration (TFF)
- Reverse osmosis (RO)
Solid Form Screening- Crystal Engineering of PDCs to improve batch-to-batch consistency
- Enhancement of physicochemical characteristics (i.e. particle size distribution, flow properties)
- Improvement to filtration and drying times
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