Separations CapacityWhen your project requires an economic, efficient, scaleable process, the combination of our chemistry expertise, complemented by our full range of separation technologies, is exactly what you are looking for. Our goal is to do what is best for you and your project. We will evaluate all applicable separation methods in our toolbox including SFC and preparative HPLC as a part of a comprehensive chemistry and separation strategy. We have development through commercial scale equipment to accommodate gram-scale purifications through multi-metric ton quantities. SFC:Supercritical Fluid Chromatography utilizes supercritical CO2 as a replacement for traditional non-polar organic solvents and is particularly useful for purification of materials with poor solution stability. Pharma Materials houses the largest SFC unit in North America, which is built and operated in full compliance with cGMP guidelines. This unit, the SUPERSEP 200, utilizes 20 cm ID columns with a CO2 recycling system to minimize the solvent requirements for the purification. Purified fractions are separated from CO2 in gas-liquid cyclonic separators. The Pressure is dropped to precipitate/liquefy the solutes in the cyclones. Our unique separations capabilities and development-oriented staff can resolve your chromatography challenges when chromatography simply cannot be avoided. Preparative HPLC: We employ preparative HPLC for the purification of multi-component mixtures when traditional purification means aren’t viable.
Our systems utilize 10 to 50 cm ID columns with pumps that produce flow rates up to 600 L/hr. The 50 cm column holds approximately 50 kg of solid phase and is custom packed on site with commercially available phase. Our preparative HPLC unit utilizes Thin Film Evaporators (TFEs) to concentrate eluant streams. We have two one-square-foot TFEs and two five-square-foot TFEs that accommodate the eluant streams. The TFEs, in combination with a solvent recycling system, support an economically feasible process.
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